Myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder marked by fluctuating weakness of voluntary muscles. Although the disease primarily affects the neuromuscular junction, electrolyte imbalances can influence muscle function and may worsen symptoms. This study focused on evaluating serum sodium, potassium, and chloride levels in MG patients attending the neurology clinic at Imo State Teaching Hospital, Orlu. A crosssectional study was conducted on 50 participants-25 MG patients and 25 healthy controls matched for age and sex. Five millliliters of blood samples were collected and analyzed using the ion-selective electrode method. The results showed that MG patients had significantly lower sodium (130.72 ± 3.84 mmol/L) and chloride (82.44 ± 7.59 mmol/L) levels compared with controls, while potassium levels (4.33 ± 0.53) mmol/L were significantly higher (p= 0.001 and < 0.0001). Potassium levels were significantly raised among ages 20-40 years compared to ages >40 years. No genderrelated differences in electrolyte levels were found among MG patients. In conclusion, participants aged 20–40 years demonstrated higher potassium levels than those aged >40 years, likely due to better renal function, higher muscle mass, and dietary habits.These findings suggest that hyponatremia, hypochloremia, and mild hyperkalemia may be part of the biochemical profile in MG, emphasize the need for age-specific considerations in electrolyte monitoring and dietary counseling to maintain optimal potassium balance across the lifespan, and that monitoring these electrolytes could improve clinical management.