Thyroid disorders are among the most prevalent endocrine conditions globally.Whileconventionaltherapynormaliz es biochemistry, residual symptoms and patient-reported outcomes often remain suboptimal. Individualized Homoeopathy— guidedbyMateria Medica—may complement endocrine regulation. Objective: To evaluate clinical outcomes and biochemical changes (TSH, free T3, free T4) in patients with thyroid dysfunction managed with individualized Homoeopathic remedies, and to correlate improvements with Materia Medica keynotes. Methods:A12- week,prospective,observational study in an ambulatory setting included adults with hypothyroidism or subclinical hyperthyroidism. Individualized remedies were selected from Materia Medica (Calcarea carbonica, Lycopodium, Sepia, Natrum muriaticum, Iodum, Thyroidinum, etc.) based on totality with emphasis on keynote alignment. Primary outcomes: change in TSH, fT3, fT4. Secondary outcomes: Fatigue VAS (0–10), ThyPRO-39 global score, and clinical global impression (CGI-I). Paired tests analyzed within-groupchange(α=0.05). Results: N=56 (hypothyroid n=44; subclinical hyper n=12). Mean TSH fell from 8.21±2.94 to 4.97±2.41 mIU/L (p<0.001). fT3 rose from 2.61±0.42 to 2.89±0.48 pg/mL (p=0.002); fT4 rose from 0.86±0.15 to 0.95±0.17 ng/dL (p=0.004). Fatigue VAS improved from 7.1±1.3 to 3.9±1.4 (p<0.001); ThyPRO global scores improved by 28%. CGI-I showed ―much/very much improved‖ in 64.3%. Remedies most associated with improvement:Calcareacarbonica(constitutio nal chilliness, perspiration, craving eggs; 32%), Lycopodium (evening aggravation, bloating, anticipatory anxiety; 20%), Natrum muriaticum (headache, salt craving, grief; 14%), Sepia (ptosis of energy, bearingdown; 11%), Iodum (hypermetabolic features; 7%), Thyroidinum (organ-remedy adjunct;