The most popular technique for eliminating extra fluid, salt, and waste from the blood is hemodialysis. Dialysis wasn't always a pleasant experience. The symptoms include fatigue, cramps, headaches, nausea, and dizziness, which can range from mild to severe. A study was done to determine the effectiveness of intradialytic leg exercise on fatigue among patients undergoing hemodialysis at a selected hospital in Chengalpattu district. The aim of this study was to evaluate the effect of intradialytic leg exercises on fatigue among patients receiving hemodialysis and to associate the level of fatigue with the selected demographic variables among patients undergoing hemodialysis. Methods: A quantitative research approach of quasi-experimental pre- and post-test with a comparison group design was used for this study. Out of 60 samples, 30 participants were allotted to the study group, and 30 were allotted to the comparison group. Pre- and post-test data were collected using structured instruments. The level of fatigue among patients undergoing hemodialysis was assessed using a standardized fatigue assessment scale, a five-point Likert scale. Comparison group participants underwent routine care, while the study group underwent intradialytic leg exercise along with routine care. The level of fatigue was evaluated for both groups using the same scale after 4 weeks. Both descriptive and Inferential statistics were computed to evaluate the level of fatigue between the study and comparison group