The rapid advancement of Artificial Intelligence(AI)hassignificantly transformed the functioning of Higher Education Institutions (HEIS) across the globe, including in the Indian state of Assam. AI technologiesareincreasingly being integrated into teaching–learning processes, academic administration, research activities, and institutional decision-making mechanisms. This paper examines the role of Artificial Intelligence in everyday academic life and decision-making practices within Higher Education Institutions in Assam. It explores how AI-driven tools support personalized learning,student assessment,academicadvising,administrative efficiency, and data-driven governance in colleges and universities. The study also highlights the potential of AI in improving institutional planning, quality assurance, and policy formulation through predictive analytics and real-time data processing. At the same time, the paper discusses key challenges such as infrastructural limitations, digital divide, lack of trained manpower, ethical concerns, data privacy issues, and resistance to technological change prevalent in HEIS of Assam. By adopting a conceptual and analytical approach based on existing literature and regional context, the paper emphasizes the need for a balanced, ethical, and inclusive adoption of AI in higher education. The study concludes that effective integration of AIcanenhanceacademic quality, institutional effectiveness, and informed decision-making in Assam’shigher education system, provided adequate policy support, capacity building, and digital infrastructure are ensured.