The advancement of organ donation has become a significant medical practice across the globe. In Nigeria, as in other parts of the world, Christianity, and other religious beliefs, tends to shape attitudes to organ donation, both on an individual and communal level. This work examines the practice on organ donation across several Christian denominations in Nigeria - Roman Catholicism, Anglicanism, Baptists, and some Pentecostal teachings - within theological and ethical frameworks, as well as the Christian Church traditions pertaining to the organ donation practice. In exploring Christian teachings, the author examines Christian theology, ethical discourse, and the teachings of other faiths and denominations within the context of ethical reasoning. A further discourse on Christian life and teachings spans the ethical discourse of the organ donation practice—the teachings on the sanctity of life, and the ethical tension within life donation—the balance between autonomy and coercion. Most traditions within Christianity in Nigeria tend to embrace forcible organ donation as an act of charity, hence the donation and doctrines embrace donation within the practice. The author presents the harmonization of health and faith as a guide to develop policy, ethics in medicine, theological education, and research.