Especially,in,societieswherefaith institutions shape public life, religion influences social attitudes and moral structuring. This study examines the complex interaction of the Church in Nigeria as both a supporter and discriminator of individuals living with HIV and AIDS. Many churches dedicate resources through counseling and social programs and run awareness campaigns, but certain theological interpretations, along with the practices of congregations, have also amplified stigma and marginalization. Employing a theological–philosophical and sociological approach, this research examines how varied Christian doctrines and pastoral practices influence perceptions of HIV/AIDS across diverse Nigerian faith communities. This study used qualitative research methods, particularly literature analysis and theological reflection, to analyze the doctrinal underpinnings, pastoral strategies, and community action of selected denominations, namely, Catholic, Anglican, Pentecostal, and African Independent Churches. Churches can be important venues for HIV/AIDS stigma reduction. Still, underinclusive responses to HIV/AIDS are a result of moralizing attitudes and teachings that frame illness as punitive. In HIV/AIDS care, denominational attitudes vary. Some churches center the discourse on social justice and healthcare, while others focus on spiritual healing and moral rectitude. The study proposes that the Church can contribute positively only after a significant theologicalshift that emphasizes compassion and human dignity along with inclusion. Recommendations include the reformation of doctrine, the incorporation of anti-stigma theology during ministerial training, the strengtheningoffaith-based health initiatives, collaborationacrossdenominations, advocacy for policies, and the development of integrated health programs. This research adds to the theological, philosophical, and public health discourse by providing a nuanced understanding of the role of religion in the stigma surrounding HIV/AIDS in Nigeria