The kinetics of the rapid iodination of 4-chloroacetanilide with iodine monochloride were examined in aqueous solution across five temperatures. The process proved to be markedly fast and second-order overall, displaying a half-life of 480 s and a rate constant of 4.16 M⁻¹ s⁻¹ at 23 °C. Because of the high speed of the reaction, hydrodynamic voltammetry was employed to monitor the progress of iodination. From the measurements, the specific rate constant, activation energy, entropy of activation and the pre-exponential factor were obtained. These kinetic and thermodynamic quantities permit a direct assessment of the reactivity of 4 chloroacetanilide under the conditions studied. [1]

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