Background: Maternal anemia is a severe pathophysiological consequence of Plasmodium falciparum infection during pregnancy. This study determines the specific prevalence and structural distribution of maternal anemia among malaria-infected pregnant women at Plateau State Specialist Hospital (PSSH). Methods: Utilizing data from a 10-year retrospective window (2012–2022), hematological variables—specifically Packed Cell Volume (PCV) values—were extracted from the records of n=122 confirmed gestational malaria cases within a baseline population of N=1,000. Anemia was defined as PCV <30%. Results: Out of the total cohort, 109 women presented with clear clinical anemia, establishing a point prevalence of 10.9% (or 11% within the global population), meaning 89.3% of the malaria-positive patients were concurrently anemic. Genotypic distribution among the cohort showed that 73.7% were Genotype AA, 9.0% were AS, and 17.3% were homozygous SS. Conclusion: Severe hematological depletion is an almost universal complication among malaria-positive pregnant patients at PSSH. Protective policies, including early iron/folate therapies and aggressive intermittent preventive therapy, must be optimized.

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