This study was carried out to ascertain the level of awareness and knowledge of mothers on childhood immunization in Maiha Local Government Area, Adamawa State Nigeria. In order to successfully carry out the study, one research questions were raised. A self-structured questionnaire with a 0.78 cronbach alpha internal consistency score, was administered to 150 respondents but 140 was returned of which 139 was found valid for analysis (92.7% return rate). Data was analyzed using simple percentage count and presented in various charts. It was found that majority of the mothers are not aware of the vaccines given to children 0-5 years and the diseases they prevent but are aware of the time interval within which the vaccine is given to the children, as wells as the venues and personnel of immunization probably due to frequent visitation. The need for a well rooted awareness campaign in the local government area on the vaccines, the diseases they prevent and the time interval within which they are given to child aged 0- 5 years among others were recommended.