Technological innovations are revolutionizing healthcare delivery; however, nurses' knowledge and attitudes play pivotal roles in their adoption. This study assessed nurses' knowledge and attitudes toward technological innovations in healthcare at Orile Agege General Hospital and proposed actionable solutions. Employing a descriptive survey design, a sample of 146 nurses was drawn from the target population using convenience sampling. Data were collected via a selfdeveloped Google Forms questionnaire and analysed with SPSS version 27.0 to test two hypotheses. A pilot test with 15 nurses from Alimosho General Hospital, Igando, yielded a Cronbach's alpha of 0.82 via chi-square analysis, confirming instrument reliability. Results indicated that 82.1% of nurses demonstrated good knowledge levels and 63.7% held positive attitudes toward technological innovations, though barriers such as financial constraints, educational attainment, technological complexity, and organizational culture impeded attitudes. Hypothesis testing revealed no significant association between nurses' knowledge and attitudes (p > .05), but a significant relationship existed between attitudes and years of experience (p < .05). Accordingly, the study recommends integrating targeted technology training into nursing curricula and practice, alongside motivational organizational strategies to foster positive attitudes. These measures will empower nurses to harness innovations effectively, ultimately improving patient outcomes across healthcare systems.