This study examines the strategic role of the African Development Bank (AFDB) in driving sustainable economic growth across Africa. Using a quantitative research design with secondary data from 2015 to 2025, the paper evaluates the impact of AFDB's financial interventions on regional GDP growth. The structural equation modeling (SEM) results reveal that capital investments in regional transport networks and energy sectors yield the highest multiplier effect on economic output. Conversely, bureaucratic delays in loan disbursement significantly diminish project efficacy. The study concludes that the AFDB serves as a primary catalyst for African development but requires operational streamlining. The structural transformation of Africa’s macroeconomic landscape remains one of the most critical development challenges of the 21st century. Despite robust demographic growth, expanding urbanization, and vast natural resource endowments, the African continent continues to navigate severe structural bottlenecks. Chief among these deficits are fragmented regional markets, energy poverty, and a prohibitive infrastructure funding deficit estimated by the African Development Bank (AFDB) to hover between $130 billion and $170 billion annually. Historically, bilateral and multilateral aid architectures have attempted to address these gaps through disparate project-based financing. However, the introduction of the AFDB’s "High 5" strategic agenda—comprising Light up and Power Africa, Feed Africa, Industrialize Africa, Integrate Africa, and Improve the Quality of Life for the People of Africa—marked a paradigm shift toward target-driven, high-multiplier capital allocation. This study contextualizes the role of the AfDB not merely as a conventional development lender, but as a primary architect of African economic resilience. It evaluates how deliberate capital deployment under these strategic pillars influences macroeconomic stability, industrial output, and cross-border trade optimization across Regional Member Countries (RMCs) amidst compounding global economic shocks