Wheelchair prescription for individuals with mobility impairment is a highly complex and challenging clinical intervention. Evidence exists that successful outcomes are not always achieved for the wheelchair user and that therapist are experiencing increasing pressure to be accountable for and to justify their wheelchair prescription practice (Gallagher et al., 2022: Dimarco et al., 2003). Unfortunately, only a minority of those who require wheelchairs have access to them, and of these only few have access to appropriate wheelchairs that suit their specific needs. It has been noted that wheelchair prescription has been poorly linked to clients need and environmental conditions affecting client engagement and participation in real life events. Aim: The study aimed to evaluate the wheelchair prescription process in Ghana and Client satisfaction with it use. Methodology: The study employed a quantitative crosssectional study. This was to enable the researcher gather data across a wide range of participants with varying backgrounds. The study was conducted at five different places: Orthopedics and Physiotherapy unit of the Korle-Bu Teaching Hospital, Accra Rehabilitation Centre, Mephibosheth special school and New Horizon special school. The study population included all people with disability who are currently using wheelchair and are above the age of ten. Participants recruited for this study were one hundred and ten. The number of participants that took part in the study was sixty, representing 54% of the proposed sample size. Participants who had their wheelchair from clinician and Therapist topped the chat with 35% representing 21participants. The study showed that the factors that ensured quality prescription were not carefully considered by the clinicians. The percentage of participants who had no training and education on wheelchair use, no involvement in the prescription process and no environmental consideration were 26.7%, 53.3% and 26.7%, respectively. This amounted to their very low participation in activities, with a mean score of 6.237 ±1.85 (on a 0 to 10 rating scale). More than half of the sample size had less than 70 as their mean satisfaction score.