This study evaluated the effectiveness of house-to-house inspection practice among public health inspectors in Keffi Local Government Area of Nasarawa State, Nigeria. A cross-sectional design was employed, using a combination of quantitative and qualitative methods to collect and analyze data from 300 public health inspectors and 1,200 households. The study revealed that 40.0% of public health inspectors have 2-5 years of experience, and 40.0% conduct house-to-house inspections weekly. Lack of resources was identified as a major challenge (60.0%), while 90.0% of public health inspectors believe that houseto-house inspection practice is effective in reducing environmental health hazards. The study highlights the need for additional resources, training, and support to enhance the effectiveness of house-to-house inspections. The findings have implications for policy and practice, suggesting the need for a functional referral system and a houseto-house inspection policy to guide public health inspectors.