The escalating cost and diminishing availability of fishmeal as the primary protein source in aquaculture diets necessitate the evaluation of sustainable and cost-effective alternatives. This study investigated the effects of poultry offal meal (POM) at graded inclusion levels (0%, 25%, 50%, 75%, and 100% replacement of fishmeal) on the growth performance, feed utilization, and body composition of Clarias gariepinus fingerlings over a 70-day feeding trial. A total of 150 fingerlings (mean initial weight: 5.60 ± 0.12 g) were randomly distributed into five dietary treatment groups in triplicate (10 fish per replicate) and fed experimental diets at 5% body weight twice daily. Growth parameters including weight gain (WG), specific growth rate (SGR), feed conversion ratio (FCR), protein efficiency ratio (PER), and survival rate (SR) were assessed. Results indicated that fish fed 25–50% POM replacement diets showed no significant difference (p > 0.05) in growth performance compared to the control (0% POM). However, groups fed 75% and 100% POM replacement exhibited significantly lower (p < 0.05) weight gain, SGR, and PER, alongside higher FCR values. Carcass analysis revealed no significant difference in crude protein, ash, and lipid content among dietary treatments. The best feed conversion ratio (2.07) was obtained at 50% POM inclusion. The study concludes that poultry offal meal can replace up to 50% of fishmeal in C. gariepinus fingerling diets without adverse effects on growth or feed utilization, offering a viable, locally available, and economically sustainable protein source for aquaculture feed formulation