This study investigated the effect of computer assisted instructions and computer animation on the teaching of Chemistry in secondary schools in Mkpat Enin Local Government Area. A quasi-experimental research design was employed for the study. The population of this study consisted of 1,473 senior secondary two students (SS2) in the sixteen (16) public secondary schools in Mkpat Enin Local Government Area. The sample size consisted of 94 Senior Secondary Two (SS2) students selected from two randomly chosen schools in the study area. Data were collected using the Chemistry Performance Test (CPT), which was validated by experts in the Department of Science Education, Akwa Ibom State University, and had a reliability coefficient of 0.79. Mean, standard deviation, and independent t-test were employed to analyze the data at a 0.05 significance level. The results revealed that there is a significant difference in the mean performance scores of students taught the concept of periodic table using computer assisted instruction and computer animation. There is no significant difference in the mean performance scores of male and female students taught the concept of periodic table using computer assisted instruction and computer animation instructional approach. Based on these findings, it is recommended that teachers adopt CAI as an integral part of their Chemistry teaching strategies for effective teaching and learning process.