We report the case of a 70-year-old man whose medical history is characterized by cardiac arrhythmia (atrial fibrillation diagnosed 2 months ago) and hypertension. He is being treated with Xarelto, statins, amlodipine and Cordarone (since 2 months). He presents with rapidly progressive bilateral loss of visual acuity. His visual acuity was 2/10 in the right eye and 6/10 in the left eye. Examination of the fundus revealed a bilateral verticillate cornea. anertior segment examination showed bilateral verticillata cornea, Fundus examination reveals bilateral papilledema OCT Fluorescein and indocyanine green (ICG) angiography confirmed bilateral papilledema Imaging and blood tests were negative In the absence of an identifiable cause for the bilateral optic neuropathy, after normal results for all tests and imaging, and given the stable appearance of bilateral papilledema after 2 weeks, amiodarone was discontinued in consultation with his cardiologist and switched to flecainide. Three weeks after discontinuation of amiodarone, the bilateral papilledema resolved and bilateral visual acuity improved progressively. Two months after discontinuation of amiodarone, the ophthalmologic examination revealed a visual acuity of 7/10 in the right eye and 10/10 in the left eye, a regression of the papilledema as well as the development of temporal disk pallor in both eyes.