This study investigated the attitudes and perceptions of student nurses at Lagos State College of Nursing, Igando, toward individuals with disabilities. Objectives included evaluating these attitudes and perceptions, identifying influencing factors, and examining the potential impact of integrating disability care into nursing curricula on service provision. A descriptive crosssectional design was utilized, with primary data gathered from 174 student nurses via stratified sampling. Data management occurred in Microsoft Excel, followed by analysis using SPSS version 27. Descriptive statistics (frequencies and percentages) summarized findings, and chi-square testing assessed the hypothesis at α = 0.05. Demographically, 143 (82.2%) respondents were female, and 81 (46.6%) were aged 21–23 years. Results indicated predominantly positive and inclusive attitudes, with 71 (40.8%) disagreeing that they felt uncomfortable around people with disabilities; additionally, 89 (51.1%) agreed and 53 (30.5%) strongly agreed that such individuals deserve equal opportunities. Nonetheless, 80 (46.0%) endorsed specialized educational centers for people with disabilities, highlighting nuanced views on inclusion. Key influencers encompassed nursing education (85 [48.9%] agreed it shaped perspectives positively) and clinical exposure (78 [44.8%] reported heightened care confidence). Moreover, 86 (49.4%) advocated for expanded disability care training. Chi-square analysis (χ² = 3.652, p = 0.302) revealed no significant association between educational level and attitudes, indicating uniform positivity across cohorts. Recommendations emphasize strengthening disability-inclusive content in nursing programs. In summary, student nurses exhibited generally favourable and inclusive orientations toward people with disabilities