Prostate cancer is a common cancer that grows slowly and tends to metastasize to bones, lungs, and the liver. Most Malignancies have established patterns in presentation, localization, and organ where they metastasize. Objective: The purpose of this study was to evaluate the levels of packed cell volume (PCV), red blood cell(RBC), total protein, and albumin in patients diagnosed with prostate cancer. Method: This was a cross-sectional study carried out at Imo Specialist Hospital, Umuguma, Owerri, Imo State, Nigeria, from the month of May to August, 2023. This study consisted of 50 male patients with prostate cancer and an equivalent number of age – matched apparently healthy subjects who served as the controls. Blood Samples collected for PCV, RBC, total protein and albumin were analyzed using standard laboratory methods. Result: The mean values of PCV (27.84.±4.62) %, RBC (3.152±3.47) x1012/μL, and Albumin (2.42±6.47)g/dl, were significantly lower in prostate cancer patients when compared to controls(36.86±3.18)%,(5.97±8.96) x1012/μL, and (4.93±9.01)g/dl (p-0.000), while the mean value of total protein (2.43±64)mg was significantly higher in prostate cancer when compared to controls (5.50+1.47) (p=0.000). Conclusion: This study has shown that prostate cancer alters the levels of PCV, RBC, total protein and albumin. Therefore, early evaluation of these parameters is encouraged to monitor prostate cancer patients and prevent complications.